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Title: Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036
Authors: Yuki Inahashi
Masato Iwatsuki
Aki Ishiyama
Atsuko Matsumoto
Tomoyasu Hirose
Jun Oshita
Toshiaki Sunazuka
Watanalai Panbangred
Yoko Takahashi
Marcel Kaiser
Kazuhiko Otoguro
Satoshi O'mura
Kitasato University
Mahidol University
Swiss Tropical and Public Health Institute (Swiss TPH)
Universitat Basel
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 20-Feb-2015
Citation: Organic Letters. Vol.17, No.4 (2015), 864-867
Abstract: © 2015 American Chemical Society. Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.
ISSN: 15237052
Appears in Collections:Scopus 2011-2015

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