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|Title:||Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036|
Swiss Tropical and Public Health Institute (Swiss TPH)
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Organic Letters. Vol.17, No.4 (2015), 864-867|
|Abstract:||© 2015 American Chemical Society. Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.|
|Appears in Collections:||Scopus 2011-2015|
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