Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/35500
Title: Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007-2010) - TASER-S
Authors: Awachana Jiamsakul
Sunee Sirivichayakul
Rossana Ditangco
Ka Hing Wong
Patrick C.K. Li
Jutarat Praparattanapan
Praphan Phanuphak
Edelwisa Segubre-Mercado
Wing Cheong Yam
Thira Sirisanthana
Thida Singtoroj
Matthew Law
M. P. Lee
N. Kumarasamy
S. Saghayam
S. Pujari
K. Joshi
T. P. Merati
F. Yuliana
C. K.C. Lee
B. L.H. Sim
A. Kamarulzaman
L. Y. Ong
M. Mustafa
N. Nordin
R. O. Bantique
Y. M.A. Chen
Y. T. Lin
S. Sungkanuparph
S. Kiertiburanakul
L. Chumla
P. Kantipong
P. Kambua
W. Ratanasuwan
R. Sriondee
R. Kantor
A. H. Sohn
N. Durier
T. Singtoroj
D. A. Cooper
M. Law
D. C. Boettiger
University of New South Wales (UNSW) Australia
Chulalongkorn University
Gokila
Integrated Treatment Centre
Queen Elizabeth Hospital Hong Kong
Chiang Mai University
The University of Hong Kong
amfAR - The Foundation for AIDS Research
VHS Medical Centre India
Institute of Infectious Diseases
Universitas Udayana
Hospital Sungai Buloh
University of Malaya
Hospital Raja Perempuan Zainab II
Kaohsiung Medical University
The HIV Netherlands Australia Thailand Research Collaboration
Mahidol University
Chiangrai Prachanukroh Hospital
Brown University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 13-Feb-2015
Citation: AIDS Research and Therapy. Vol.12, No.1 (2015)
Abstract: © Jiamsakul et al. Background: The availability of HIV antiretroviral therapy (ART) has been associated with the development of transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients initiating ART and the prevalence can vary in different clinical settings. In this study, we investigated the proportion of TDRM in treatment-naïve, recently infected HIV-positive individuals sampled from four urban locations across Asia between 2007-2010. Methods: Patients enrolled in the TREAT Asia Studies to Evaluate Resistance - Surveillance Study (TASER-S) were genotyped prior to ART initiation, with resulting resistance mutations analysed according to the WHO 2009 list. Results: Proportions of TDRM from recently infected individuals from TASER-S ranged from 0% to 8.7% - Hong Kong: 3/88 (3.4%, 95% CI (0.71%-9.64%)); Thailand: Bangkok: 13/277 (4.7%, 95% CI (2.5%-7.9%)), Chiang Mai: 0/17 (0%, 97.5% CI (0%-19.5%)); and the Philippines: 6/69 (8.7%, 95% CI (3.3%-18.0%)). There was no significant increase in TDRM over time across all four clinical settings. Conclusions: The observed proportion of TDRM in TASER-S patients from Hong Kong, Thailand and the Philippines was low to moderate during the study period. Regular monitoring of TDRM should be encouraged, especially with the scale-up of ART at higher CD4 levels.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84924274629&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/35500
ISSN: 17426405
Appears in Collections:Scopus 2011-2015

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