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Title: Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes
Authors: Hanan L. Messiha
Thanyaporn Wongnate
Pimchai Chaiyen
Alex R. Jones
Nigel S. Scrutton
University of Manchester
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Engineering;Materials Science
Issue Date: 6-Feb-2015
Citation: Journal of the Royal Society Interface. Vol.12, No.103 (2015)
Abstract: © 2014 The Author(s). Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue-a reaction known to proceed via a radical pair. Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction kinetics from stopped-flow measurements in any of the systems studied. Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzymecatalysed reactions are unlikely to be influenced by exposure to external magnetic fields.
ISSN: 17425662
Appears in Collections:Scopus 2011-2015

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