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dc.contributor.authorOrn Uma Yanpanitchen_US
dc.contributor.authorSuneerat Hatairakthamen_US
dc.contributor.authorRatiya Charoensakdien_US
dc.contributor.authorNarumol Panichkulen_US
dc.contributor.authorSuthat Fucharoenen_US
dc.contributor.authorSomdet Srichairatanakoolen_US
dc.contributor.authorNoppadol Siritanaratkulen_US
dc.contributor.authorRuchaneekorn W. Kalpravidhen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChiang Mai Universityen_US
dc.date.accessioned2018-11-23T09:49:21Z-
dc.date.available2018-11-23T09:49:21Z-
dc.date.issued2015-01-01en_US
dc.identifier.citationOxidative Medicine and Cellular Longevity. Vol.2015, (2015)en_US
dc.identifier.issn19420994en_US
dc.identifier.issn19420900en_US
dc.identifier.other2-s2.0-84930958570en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930958570&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/35587-
dc.description.abstract© 2015 Orn-uma Yanpanitch et al. Studies on the antioxidant treatment for thalassemia have reported variable outcomes. However, treatment of thalassemia with a combination of hydrophobic and hydrophilic antioxidants and an iron chelator has not been studied. This study investigated the effects of antioxidant cocktails for the treatment of β-thalassemia/hemoglobin E (HbE), which is the most common form of β-thalassemia in Southeast Asia. Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, and either curcuminoids (CUR) or vitamin E (Vit-E), and their hematological parameters, iron load, oxidative stress, and blood coagulation potential were evaluated. Patients were classified as responders if they showed the improvements of the markers of iron load and oxidative stress, otherwise as nonresponders. During treatment, the responders in both groups had significantly decreased iron load, oxidative stress, and coagulation potential and significantly increased antioxidant capacity and hemoglobin concentration. The significantly maximum increase (P < 0.01) in hemoglobin concentration was 11% at month 4 in CUR group responders and 10% at month 10 in Vit-E group responders. In conclusion, the two antioxidant cocktails can improve anemia, iron overload, oxidative stress, and hypercoagulable state in β-thalassemia/HbE.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930958570&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleTreatment of β -thalassemia/hemoglobin e with antioxidant cocktails results in decreased oxidative stress, increased hemoglobin concentration, and improvement of the hypercoagulable stateen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1155/2015/537954en_US
Appears in Collections:Scopus 2011-2015

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