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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/35588
Title: Common variations in the FTO gene and obesity in Thais: A family-based study
Authors: Wanida Chuenta
Benjaluck Phonrat
Anchalee Tungtrongchitr
Chanin Limwongse
Nalinee Chongviriyaphan
Jeerunda Santiprabhob
Rungsunn Tungtrongchitr
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2015
Citation: Gene. Vol.558, No.1 (2015), 75-81
Abstract: © 2014 Elsevier B.V. Several studies have revealed the association between single nucleotide polymorphisms (SNPs) in the first intron of fat mass and obesity-associated (. FTO) gene and obesity. To date, more than 100 SNPs in the FTO gene have been identified in various populations. Nevertheless, this association has not yet been confirmed in Thai populations. The aim of this study was to investigate whether FTO variants are associated with obesity in Thais. We analyzed ten variants in the FTO gene (rs9939609, rs9926289, rs8050136, rs9930501, rs9930506, rs9940646, rs9940128, rs1421085, rs17817449, and rs8043757) in 12 families (83 persons); composed of 12 proband cases and 71 associated family members. All participants were genotyped using polymerase chain reaction (PCR) method and DNA sequencing assay. We found significant associations between three SNPs located in the first intron of FTO gene (rs1421085, rs17817449, and rs8043757) and obesity. The odds ratios were 2.82 (95% CI, 1.16-6.90, p=. 0.02) for rs1421085 and rs17817449, and 3.15 (95% CI, 1.28-7.76, p=. 0.01) for rs8043757. Strong linkage disequilibrium among ten SNPs was observed (D'. >. 0.8). Haplotype analysis (combination of rs1421085 (T/C), rs17817449 (T/G), and rs8043757 (A/T)) showed that the CGT haplotype is associated with an increased risk of obesity (OR, 2.42; 95% CI, 1.18-4.97; p=. 0.018) when compared to the reference haplotype (TTA). The SNPs rs1421085, rs17817449 and rs8043757 in the first intron of the FTO gene are associated with increasing risk of obesity in Thais.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84923627606&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/35588
ISSN: 18790038
03781119
Appears in Collections:Scopus 2011-2015

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