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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/35620
Title: Optimization and evaluation of reconstruction-based compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT
Authors: Tawatchai Ekjeen
Chiraporn Tocharoenchai
Pawana Pusuwan
George S.K. Fung
Michael Ghaly
Yong Du
Eric C. Frey
Mahidol University
Faculty of Medicine, Siriraj Hospital, Mahidol University
Johns Hopkins University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2015
Citation: Physica Medica. Vol.31, No.2 (2015), 159-166
Abstract: © 2014 Associazione Italiana di Fisica Medica. The value of Tc-99m MIBI parathyroid SPECT for localizing parathyroid hyperplasia in chronic renal failure patients remains inconclusive due to limited image quality. Advanced reconstruction methods to improve image quality have been developed but require optimization and evaluation. The goal of this study was to optimize and evaluate compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT. A phantom population and projection data that modelled clinically realistic variations found in patients were simulated. The 3D OS-EM reconstruction with compensation for attenuation, detector response and scatter in various combinations were studied. For each compensation, the number of updates for OS-EM and the cutoff frequency of a 3D Butterworth filter were optimized and evaluated using anthropomorphic model observer. With optimal parameters, the method with compensation for attenuation and detector response, with or without the addition of scatter compensation, provided the highest lesion detectability for Tc-99m MIBI parathyroid SPECT.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84921767375&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/35620
ISSN: 1724191X
11201797
Appears in Collections:Scopus 2011-2015

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