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Title: Evaluation of antibacterial activity of some traditionally used medicinal plants against human pathogenic bacteria
Authors: Bishnu P. Marasini
Pankaj Baral
Pratibha Aryal
Kashi R. Ghimire
Sanjiv Neupane
Nabaraj Dahal
Anjana Singh
Laxman Ghimire
Kanti Shrestha
Tribhuvan University
Nepal Academy of Science and Technology (NAST)
Louisiana State University
Mahidol University
Friends of Patan Hospital Nepal
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: BioMed Research International. Vol.2015, (2015)
Abstract: © 2015 Bishnu P. Marasini et al. The worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. We aimed to find the in vitro antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of Nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method. The evaluated plants species were found to exert a range of in vitro growth inhibitory action against the tested bacterial species, and Cynodon dactylon was found to exhibit moderate inhibitory action against 13 bacterial species including methicillin-resistant Staphylococcus aureus, imipenem-resistant Pseudomonas aeruginosa, multidrug-resistant Salmonella typhi, and S. typhimurium. The minimum inhibitory concentration (MIC) values of tested ethanolic extracts were found from 31 to >25,000 g/mL. Notably, ethanolic extracts of Cinnamomum camphora, Curculigo orchioides, and Curcuma longa exhibited the highest antibacterial activity against S. pyogenes with a MIC of 49, 49, and 195 g/mL, respectively; whereas chloroform fraction of Cynodon dactylon exhibited best antibacterial activity against S. aureus with a MIC of 31 g/mL. Among all, C. dactylon, C. camphora, C. orchioides, and C. longa plant extracts displayed a potential antibacterial activity of MIC < 100 g/mL.
ISSN: 23146141
Appears in Collections:Scopus 2011-2015

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