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Title: Antibody-mediated complement C3b/iC3b binding to group B streptococcus in paired mother and baby serum samples in a refugee population on the Thailand-Myanmar border
Authors: Jenny Herbert
Stephen Thomas
Charlotte Brookes
Claudia Turner
Paul Turnerd
Francois Nostend
Kirsty Le Doare
Michael Hudson
Paul T. Heath
Andrew Gorringe
Stephen Taylor
Public Health England
Nuffield Department of Clinical Medicine
Mahidol University
Angkor Hospital for Children
Imperial College London
St George's University of London
University of Birmingham
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: Clinical and Vaccine Immunology. Vol.22, No.3 (2015), 319-326
Abstract: Copyright © 2015 American Society for Microbiology. All Rights Reserved. Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations.
ISSN: 1556679X
Appears in Collections:Scopus 2011-2015

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