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dc.contributor.authorJenny Herberten_US
dc.contributor.authorStephen Thomasen_US
dc.contributor.authorCharlotte Brookesen_US
dc.contributor.authorClaudia Turneren_US
dc.contributor.authorPaul Turnerden_US
dc.contributor.authorFrancois Nostenden_US
dc.contributor.authorKirsty Le Doareen_US
dc.contributor.authorMichael Hudsonen_US
dc.contributor.authorPaul T. Heathen_US
dc.contributor.authorAndrew Gorringeen_US
dc.contributor.authorStephen Tayloren_US
dc.contributor.otherPublic Health Englanden_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherAngkor Hospital for Childrenen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherSt George's University of Londonen_US
dc.contributor.otherUniversity of Birminghamen_US
dc.identifier.citationClinical and Vaccine Immunology. Vol.22, No.3 (2015), 319-326en_US
dc.description.abstractCopyright © 2015 American Society for Microbiology. All Rights Reserved. Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAntibody-mediated complement C3b/iC3b binding to group B streptococcus in paired mother and baby serum samples in a refugee population on the Thailand-Myanmar borderen_US
Appears in Collections:Scopus 2011-2015

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