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Title: Silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid effectively enhances in vitro chondrogenesis of bone marrow mesenchymal stem cells
Authors: Nopporn Sawatjui
Teerasak Damrongrungruang
Wilairat Leeanansaksiri
Patcharee Jearanaikoon
Suradej Hongeng
Temduang Limpaiboon
Khon Kaen University
Suranaree University of Technology
Mahidol University
Keywords: Engineering;Materials Science;Medicine
Issue Date: 1-Jul-2015
Citation: Materials Science and Engineering C. Vol.52, (2015), 90-96
Abstract: © 2015 Elsevier B.V. All rights reserved. Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid (SF-GCH) scaffold and showed that it could promote proliferation of human bone marrow mesenchymal stem cells (BM-MSCs). This study aimed to evaluate its biological performance as a new biomimetic material for chondrogenic induction of BM-MSCs in comparison to an SF scaffold and conventional pellet culture. We found that the SF-GCH scaffold significantly enhanced the proliferation and chondrogenic differentiation of BM-MSCs compared to the SF scaffold and pellet culture in which the production of sulfated glycoaminoglycan was increased in concordance with the up-regulation of chondrogenic-specific gene markers. Our findings indicate the significant role of SF-GCH by providing a supportive structure and the mimetic cartilage environment for chondrogenesis which enables cartilage regeneration. Thus, our fabricated SF-GCH scaffold may serve as a potential biomimetic material for cartilage tissue engineering.
ISSN: 09284931
Appears in Collections:Scopus 2011-2015

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