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Title: The correlation between intradermal testing and serum specific IGE to house dust mite in negative skin prick test allergic rhinitis adult patients
Authors: Pongsakorn Tantilipikorn
Piyanart Danpornprasert
Premyot Ngaotepprutaram
Paraya Assanasen
Chaweewan Bunnag
Bandit Thinkhamrop
Mahidol University
Khon Kaen University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2015
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.33, No.4 (2015), 308-311
Abstract: © 2009 is a Digital Portal of health science journals in Thailand. Background: Diagnosis of allergic rhinitis (AR) is based on history, physical examination, and skin prick test (SPT) while intradermal (ID) test can be performed to confirm the diagnosis in case of negative result of SPT. However, the ID test is not recommended for cat and timothy grass allergy because of its high false positive rate. As a result, the “quantitative” technique of serum specific IgE (sIgE) measurement might be helpful to diagnose AR with more confidence. Objectives: To evaluate the correlation between ID tests and sIgE in the diagnosis of house dust mite (HDM)-sensitive AR patients. Methods: Patients with chronic rhinitis (CR) were recruited and SPT was performed. If SPT was negative, ID test and sIgE to HDM [Dermatophagoides pteronyssinus (Dp)] measurement were performed. Results: Eighty-two patients with chronic rhinitis (CR), whose SPTs were negative for Dp, were included. There were 39 males (47.6%) and 43 females (52.4%) aged between 18 and 76 years old (mean age = 43.3 years). The ID test was positive in 13 patients (15.9%), and was negative in 69 patients (84.1%). sIgE to HDM was positive (≥ 0.35 kUA/l) in 2 patients (2.4%). There was a fair to moderate correlation between the size of wheal of ID test and sIgE to HDM (r = 0.44, 95% confidence interval: 0.19 to 0.67, p < 0.01). Conclusion: ID test has a fair to moderate correlation with sIgE Dermatophagoides pteronyssinus and it can be used in CR patients with negative SPT where sIgE is not feasible.
ISSN: 22288694
Appears in Collections:Scopus 2011-2015

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