Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Diagnostic accuracy assessment of immunochromatographic tests for the rapid detection of antibodies against orientia Tsutsugamushi using paired acute and convalescent specimens
Authors: Wanitda Watthanaworawit
Paul Turner
Claudia Turner
Ampai Tanganuchitcharnchai
Suthatip Jintaworn
Borimas Hanboonkunupakarn
Allen L. Richards
Nicholas P.J. Day
Stuart D. Blacksell
François Nosten
University of Oxford
Mahidol University
Angkor Hospital for Children
Nuffield Department of Clinical Medicine
Naval Medical Research Center
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2015
Citation: American Journal of Tropical Medicine and Hygiene. Vol.93, No.6 (2015), 1168-1171
Abstract: © 2015 by The American Society of Tropical Medicine and Hygiene. We assessed the diagnostic accuracy of two immunochromatographic tests (ICTs), the Access Bio Care Start Scrub Typhus test (Somerset, NJ) (IgM), and the SD BIOLINE Tsutsugamushi test (Kyonggi-do, Republic of Korea) (IgG, IgM, or IgA) compared with indirect immunofluorescence assay (IFA) and real-time PCR results as reference tests using 86 paired acute and convalescent specimens from febrile patients. The sensitivity and specificity of the Care Start test were 23.3% (95% confidence interval [CI]: 11.8-38.6) and 81.4% (95% CI: 66.6-91.6), respectively, for acute specimens and 32.6% (95% CI: 19.1-48.5) and 79.1% (95% CI: 64.0-90.0), respectively, for convalescent specimens. For the SD BIOLINE test, sensitivity and specificity were 20.9% (95% CI: 10.0-36.0) and 74.4% (95% CI: 58.8-86.5), respectively, for acute specimens and 76.7% (95% CI: 61.4-88.2) and 76.7% (95% CI: 61.4-88.2), respectively, for convalescent specimens. The poor sensitivity obtained for both ICTs during this study when performed on acute specimens highlights the difficulties in prompt diagnosis of scrub typhus.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.