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dc.contributor.authorSathit Pichyangkulen_US
dc.contributor.authorKosol Yongvanitchiten_US
dc.contributor.authorAmporn Limsalakpetchen_US
dc.contributor.authorUtaiwan Kum-Arben_US
dc.contributor.authorRawiwan Im-Erbsinen_US
dc.contributor.authorKobporn Boonnaken_US
dc.contributor.authorArunee Thitithayanonten_US
dc.contributor.authorAnan Jongkaewwattanaen_US
dc.contributor.authorSuwimon Wiboon-Uten_US
dc.contributor.authorDuangrat Mongkolsirichaikulen_US
dc.contributor.authorRangsini Mahanondaen_US
dc.contributor.authorMichele Springen_US
dc.contributor.authorIlin Chuangen_US
dc.contributor.authorCarl J. Masonen_US
dc.contributor.authorDavid L. Saundersen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.identifier.citationJournal of Immunology. Vol.195, No.9 (2015), 4378-4386en_US
dc.description.abstractCopyright © 2015 by The American Association of Immunologists, Inc. Studies of influenza-specific immune responses in humans have largely assessed systemic responses involving serum Ab and peripheral blood T cell responses. However, recent evidence indicates that tissue-resident memory T (TRM) cells play an important role in local murine intrapulmonary immunity. Rhesus monkeys were pulmonary exposed to 2009 pandemic H1N1 virus at days 0 and 28 and immune responses in different tissue compartments were measured. All animals were asymptomatic postinfection. Although only minimal memory immune responses were detected in peripheral blood, a high frequency of influenza nucleoprotein-specific memory T cells was detected in the lung at the "contraction phase," 49-58 d after second virus inoculation. A substantial proportion of lung nucleoprotein-specific memory CD8+ T cells expressed CD103 and CD69, phenotypic markers of TRM cells. Lung CD103+ and CD103- memory CD8+ T cells expressed similar levels of IFN-γ and IL-2. Unlike memory T cells, spontaneous Ab secreting cells and memory B cells specific to influenza hemagglutinin were primarily observed in the mediastinal lymph nodes. Little difference in systemic and local immune responses against influenza was observed between young adult (6-8 y) and old animals (18-28 y). Using a nonhuman primate model, we revealed substantial induction of local T and B cell responses following 2009 pandemic H1N1 infection. Our study identified a subset of influenza-specific lung memory T cells characterized as TRM cells in rhesus monkeys. The rhesus monkey model may be useful to explore the role of TRM cells in local tissue protective immunity after rechallenge and vaccination.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleTissue distribution of memory T and B cells in rhesus monkeys following influenza A infectionen_US
Appears in Collections:Scopus 2011-2015

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