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dc.contributor.authorJindarat Lohachanakulen_US
dc.contributor.authorWeerawat Phukliaen_US
dc.contributor.authorMontri Thannagithen_US
dc.contributor.authorTipparat Thongsakulpraserten_US
dc.contributor.authorDuncan R. Smithen_US
dc.contributor.authorSukathida Ubolen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPang Nga Hospitalen_US
dc.date.accessioned2018-11-23T10:17:29Z-
dc.date.available2018-11-23T10:17:29Z-
dc.date.issued2015-05-01en_US
dc.identifier.citationJournal of Medical Virology. Vol.87, No.5 (2015), 733-739en_US
dc.identifier.issn10969071en_US
dc.identifier.issn01466615en_US
dc.identifier.other2-s2.0-84925040317en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925040317&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/36110-
dc.description.abstract© 2015 Wiley Periodicals, Inc. In addition to fever, rash, and arthralgia/arthritis, myalgia is another dominant symptom in Chikungunya virus (CHIKV) infection. How CHIKV induces myalgia is unclear. To better understand the viral factors involved in CHIKV-induced myalgia, CHIKVs were isolated from patients with and without myalgia designated myalgia-CHIKV and mild-CHIKV, respectively. The response of myoblasts to infection by the two groups of clinical isolates of CHIKV was investigated. Both groups of CHIKV replicated well in primary human myoblasts. However, the myalgia-CHIKVs replicated to a higher titer and caused the death of infected myoblast more rapidly than the mild-CHIKVs. CHIKV-infected myoblasts increased production of four out of five inflammatory cytokines examined (MCP-1, IP-10, MIP-1α, and IL-8) in comparison to mock-infected cells. Comparison between the myoblast inflammatory cytokine responses showed that myalgia-CHIKVs were stronger activators of cytokines than mild-CHIKVs. This means that recent epidemic strains of CHIKV exhibited different degrees of myoblast permissiveness as evidenced by differences in the ability to replicate and to stimulate inflammatory responses in myoblasts. This data suggest that the myopathic syndrome in recent epidemics is dependent upon the strain of CHIKV. J. Med. Virol. 87:733-739, 2015.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925040317&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleDifferences in response of primary human myoblasts to infection with recent epidemic strains of Chikungunya virus isolated from patients with and without myalgiaen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1002/jmv.24081en_US
Appears in Collections:Scopus 2011-2015

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