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Title: Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Authors: Sebastian A. Mikolajczak
Ashley M. Vaughan
Niwat Kangwanrangsan
Wanlapa Roobsoong
Matthew Fishbaugher
Narathatai Yimamnuaychok
Nastaran Rezakhani
Viswanathan Lakshmanan
Naresh Singh
Alexis Kaushansky
Nelly Camargo
Michael Baldwin
Scott E. Lindner
John H. Adams
Jetsumon Sattabongkot
Stefan H.I. Kappe
Seattle Biomedical Research Institute
Mahidol University
University of South Florida Health
University of Washington, Seattle
Pennsylvania State University
Keywords: Immunology and Microbiology
Issue Date: 8-Apr-2015
Citation: Cell Host and Microbe. Vol.17, No.4 (2015), 526-535
Abstract: © 2015 Elsevier Inc. Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites-hypnozoites. The lack of tractable P. vivax animal models constitutes an obstacle in examining P. vivax liver stage infection and drug efficacy. To overcome this obstacle, we have used human liver-chimeric (huHep) FRG KO mice as a model for P. vivax infection. FRG KO huHep mice support P. vivax sporozoite infection, liver stage development, and hypnozoite formation. We show complete P. vivax liver stage development, including maturation into infectious exo-erythrocytic merozoites as well as the formation and persistence of hypnozoites. Prophylaxis or treatment with the antimalarial primaquine can prevent and eliminate liver stage infection, respectively. Thus, P. vivax-infected FRG KO huHep mice are a model to investigate liver stage development and dormancy and may facilitate the discovery of drugs targeting relapsing malaria.
ISSN: 19346069
Appears in Collections:Scopus 2011-2015

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