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dc.contributor.authorSebastian A. Mikolajczaken_US
dc.contributor.authorAshley M. Vaughanen_US
dc.contributor.authorNiwat Kangwanrangsanen_US
dc.contributor.authorWanlapa Roobsoongen_US
dc.contributor.authorMatthew Fishbaugheren_US
dc.contributor.authorNarathatai Yimamnuaychoken_US
dc.contributor.authorNastaran Rezakhanien_US
dc.contributor.authorViswanathan Lakshmananen_US
dc.contributor.authorNaresh Singhen_US
dc.contributor.authorAlexis Kaushanskyen_US
dc.contributor.authorNelly Camargoen_US
dc.contributor.authorMichael Baldwinen_US
dc.contributor.authorScott E. Lindneren_US
dc.contributor.authorJohn H. Adamsen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorStefan H.I. Kappeen_US
dc.contributor.otherSeattle Biomedical Research Instituteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of South Florida Healthen_US
dc.contributor.otherUniversity of Washington, Seattleen_US
dc.contributor.otherPennsylvania State Universityen_US
dc.date.accessioned2018-11-23T10:17:53Z-
dc.date.available2018-11-23T10:17:53Z-
dc.date.issued2015-04-08en_US
dc.identifier.citationCell Host and Microbe. Vol.17, No.4 (2015), 526-535en_US
dc.identifier.issn19346069en_US
dc.identifier.issn19313128en_US
dc.identifier.other2-s2.0-84927018652en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84927018652&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/36116-
dc.description.abstract© 2015 Elsevier Inc. Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites-hypnozoites. The lack of tractable P. vivax animal models constitutes an obstacle in examining P. vivax liver stage infection and drug efficacy. To overcome this obstacle, we have used human liver-chimeric (huHep) FRG KO mice as a model for P. vivax infection. FRG KO huHep mice support P. vivax sporozoite infection, liver stage development, and hypnozoite formation. We show complete P. vivax liver stage development, including maturation into infectious exo-erythrocytic merozoites as well as the formation and persistence of hypnozoites. Prophylaxis or treatment with the antimalarial primaquine can prevent and eliminate liver stage infection, respectively. Thus, P. vivax-infected FRG KO huHep mice are a model to investigate liver stage development and dormancy and may facilitate the discovery of drugs targeting relapsing malaria.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84927018652&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePlasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric miceen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.chom.2015.02.011en_US
Appears in Collections:Scopus 2011-2015

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