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Title: Assessment of flavaglines as potential chikungunya virus entry inhibitors
Authors: Phitchayapak Wintachai
Frédéric Thuaud
Christine Basmadjian
Sittiruk Roytrakul
Sukathida Ubol
Laurent Désaubry
Duncan R. Smith
Mahidol University
Universite de Strasbourg
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: Microbiology and Immunology. Vol.59, No.3 (2015), 129-141
Abstract: © 2015 The Societies and Wiley Publishing Asia Pty Ltd. Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that recently caused large epidemics in islands in, and countries around, the Indian Ocean. There is currently no specific drug for therapeutic treatment or for use as a prophylactic agent against infection and no commercially available vaccine. Prohibitin has been identified as a receptor protein used by chikungunya virus to enter mammalian cells. Recently, synthetic sulfonyl amidines and flavaglines (FLs), a class of naturally occurring plant compounds with potent anti-cancer and cytoprotective and neuroprotective activities, have been shown to interact directly with prohibitin. This study therefore sought to determine whether three prohibitin ligands (sulfonyl amidine 1m and the flavaglines FL3 and FL23) were able to inhibit CHIKV infection of mammalian Hek293T/17 cells. All three compounds inhibited infection and reduced virus production when cells were treated before infection but not when added after infection. Pretreatment of cells for only 15minutes prior to infection followed by washing out of the compound resulted in significant inhibition of entry and virus production. These results suggest that further investigation of prohibitin ligands as potential Chikungunya virus entry inhibitors is warranted.
ISSN: 13480421
Appears in Collections:Scopus 2011-2015

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