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Title: Competition between Burkholderia pseudomallei and B. thailandensis Ecological and evolutionary microbiology
Authors: Wikanda Ngamdee
Sarunporn Tandhavanant
Chanthiwa Wikraiphat
Onrapak Reamtong
Vanaporn Wuthiekanun
Jeanne Salje
David A. Low
Sharon J. Peacock
Narisara Chantratita
Mahidol University
University of California, Santa Barbara
University of Cambridge
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2015
Citation: BMC Microbiology. Vol.15, No.1 (2015)
Abstract: © 2015 Ngamdee et al.; licensee BioMed Central. Background: Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis, an often fatal disease in tropical countries. Burkholderia thailandensis is a non-virulent but closely related species. Both species are soil saprophytes but are almost never isolated together. Results: We identified two mechanisms by which B. pseudomallei affects the growth of B. thailandensis. First, we found that six different isolates of B. pseudomallei inhibited the growth of B. thailandensis on LB agar plates. Second, our results indicated that 55% of isolated strains of B. pseudomallei produced a secreted compound that inhibited the motility but not the viability of B. thailandensis. Analysis showed that the active compound was a pH-sensitive and heat-labile compound, likely a protein, which may affect flagella processing or facilitate their degradation. Analysis of bacterial sequence types (STs) demonstrated an association between this and motility inhibition. The active compound was produced from B. pseudomallei during the stationary growth phase. Conclusion: Taken together, our results indicate that B. pseudomallei inhibits both the growth and motility of its close relative B. thailandensis. The latter phenomenon appears to occur via a previously unreported mechanism involving flagellar processing or degradation.
ISSN: 14712180
Appears in Collections:Scopus 2011-2015

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