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Title: Blood-brain barrier function and biomarkers of central nervous system injury in rickettsial versus other neurological infections in Laos
Authors: Sabine Dittrich
Piyanate Sunyakumthorn
Sayaphet Rattanavong
Rattanaphone Phetsouvanh
Phonepasith Panyanivong
Amphonsavanh Sengduangphachanh
Phonelavanh Phouminh
Tippawan Anantatat
Anisone Chanthongthip
Sue J. Lee
Audrey Dubot-Péres
Nicholas P.J. Day
Daniel H. Paris
Paul N. Newton
Gareth D.H. Turner
Mahidol University
University of Oxford
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2015
Citation: American Journal of Tropical Medicine and Hygiene. Vol.93, No.2 (2015), 232-237
Abstract: © 2015 by The American Society of Tropical Medicine and Hygiene. Blood-brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic (N = 66), including bacterial meningitis (BM; N = 9) or tuberculosis meningitis (TBM; N = 11), Japanese encephalitis virus (JEV; N = 25), and rickettsial infections (N = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by Orientia tsutsugamushi compared with Rickettsia species.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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