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|Title:||Malaria vaccines: Identifying Plasmodium falciparum liver-stage targets|
|Authors:||Rhea J. Longley|
Adrian V.S. Hill
Alexandra J. Spencer
Nuffield Department of Clinical Medicine
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
|Keywords:||Immunology and Microbiology|
|Citation:||Frontiers in Microbiology. Vol.6, No.SEP (2015)|
|Abstract:||© 2015 Longley, Hill and Spencer. The development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past 10-15 years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however, the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite's life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening Plasmodium falciparum liver-stage targets for use in a malaria vaccine.|
|Appears in Collections:||Scopus 2011-2015|
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