Please use this identifier to cite or link to this item:
Full metadata record
|dc.contributor.author||Rhea J. Longley||en_US|
|dc.contributor.author||Adrian V.S. Hill||en_US|
|dc.contributor.author||Alexandra J. Spencer||en_US|
|dc.contributor.other||Nuffield Department of Clinical Medicine||en_US|
|dc.contributor.other||Walter and Eliza Hall Institute of Medical Research||en_US|
|dc.contributor.other||University of Melbourne||en_US|
|dc.identifier.citation||Frontiers in Microbiology. Vol.6, No.SEP (2015)||en_US|
|dc.description.abstract||© 2015 Longley, Hill and Spencer. The development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past 10-15 years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however, the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite's life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening Plasmodium falciparum liver-stage targets for use in a malaria vaccine.||en_US|
|dc.subject||Immunology and Microbiology||en_US|
|dc.title||Malaria vaccines: Identifying Plasmodium falciparum liver-stage targets||en_US|
|Appears in Collections:||Scopus 2011-2015|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.