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Title: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
Authors: Wanwisa Dejnirattisai
Wiyada Wongwiwat
Sunpetchuda Supasa
Xiaokang Zhang
Xinghong Dai
Alexander Rouvinsky
Amonrat Jumnainsong
Carolyn Edwards
Nguyen Than Ha Quyen
Thaneeya Duangchinda
Jonathan M. Grimes
Wen Yang Tsai
Chih Yun Lai
Wei Kung Wang
Prida Malasit
Jeremy Farrar
Cameron P. Simmons
Z. Hong Zhou
Felix A. Rey
Juthathip Mongkolsapaya
Gavin R. Screaton
Imperial College London
Mahidol University
Institut Pasteur, Paris
CNRS Centre National de la Recherche Scientifique
University of California, Los Angeles
Khon Kaen University
Thailand National Center for Genetic Engineering and Biotechnology
Wellcome Trust Centre for Human Genetics
Science Division
University of Hawaii at Manoa John A. Burns School of Medicine
University of Melbourne
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: Nature Immunology. Vol.16, No.2 (2015), 170-177
Abstract: © 2015 Nature America, Inc. Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus produced in either insect cells or primary human cells, with 50% neutralization in the low picomolar range. Our results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
ISSN: 15292916
Appears in Collections:Scopus 2011-2015

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