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|Title:||Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand|
Bart J. Currie
Sharon J. Peacock
Nicholas P.J. Day
Khon Kaen University
Royal Darwin Hospital
University of Cambridge
Nuffield Department of Clinical Medicine
|Keywords:||Immunology and Microbiology|
|Citation:||Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.109, No.6 (2015), 416-418|
|Abstract:||© The Author 2015. Background: Melioidosis is a common community-acquired infectious disease in northeast Thailand associated with overall mortality of approximately 40% in hospitalized patients, and over 70% in severe cases. Ceftazidime is recommended for parenteral treatment in patients with suspected melioidosis. Meropenem is increasingly used but evidence to support this is lacking. Methods: A decision tree was used to estimate the cost-effectiveness of treating non-severe and severe suspected acute melioidosis cases with either ceftazidime or meropenem. Results: Empirical treatment with meropenem is likely to be cost-effective providing meropenem reduces mortality in severe cases by at least 9% and the proportion with subsequent culture-confirmed melioidosis is over 20%. Conclusions: In this context, treatment of severe cases with meropenem is likely to be cost-effective, while the evidence to support the use of meropenem in non-severe suspected melioidosis is not yet available.|
|Appears in Collections:||Scopus 2011-2015|
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