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Title: Review of mass drug administration for malaria and its operational challenges
Authors: Gretchen Newby
Jimee Hwang
Kadiatou Koita
Ingrid Chen
Brian Greenwood
Lorenz Von Seidlein
G. Dennis Shanks
Laurence Slutsker
S. Patrick Kachur
Jennifer Wegbreit
Matthew M. Ippolito
Eugenie Poirot
Roly Gosling
University of California, San Francisco
London School of Hygiene & Tropical Medicine
Mahidol University
Australian Army Malaria Institute
Centers for Disease Control and Prevention
Johns Hopkins University
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: American Journal of Tropical Medicine and Hygiene. Vol.93, No.1 (2015), 125-134
Abstract: Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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