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Title: Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia
Authors: Katherine R.W. Emary
Michael J. Carter
Sreymom Pol
Soeng Sona
Varun Kumar
Nicholas P.J. Day
Christopher M. Parry
Catrin E. Moore
Mahidol University
Nuffield Department of Clinical Medicine
Angkor Hospital for Children
UCL Institute of Child Health
Liverpool School of Tropical Medicine
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: Tropical Medicine and International Health. Vol.20, No.1 (2015), 24-28
Abstract: © 2014 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. Objective: Antibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia. Methods: Caregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate). Results: Medication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli. Conclusions: Antibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.
ISSN: 13653156
Appears in Collections:Scopus 2011-2015

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