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dc.contributor.authorBo Wangen_US
dc.contributor.authorFeng Luen_US
dc.contributor.authorYang Chengen_US
dc.contributor.authorJun Hu Chenen_US
dc.contributor.authorHye Yoon Jeonen_US
dc.contributor.authorKwon Soo Haen_US
dc.contributor.authorJun Caoen_US
dc.contributor.authorMyat Htut Nyunten_US
dc.contributor.authorJin Hee Hanen_US
dc.contributor.authorSeong Kyun Leeen_US
dc.contributor.authorMyat Phone Kyawen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorEizo Takashimaen_US
dc.contributor.authorTakafumi Tsuboien_US
dc.contributor.authorEun Taek Hanen_US
dc.contributor.otherKangwon National Universityen_US
dc.contributor.otherAnhui Medical Universityen_US
dc.contributor.otherJiangsu Institute of Parasitic Diseasesen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherDepartment of Medical Researchen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherEhime Universityen_US
dc.contributor.otherChinese Center for Disease Control and Preventionen_US
dc.identifier.citationInfection and Immunity. Vol.83, No.8 (2015), 3083-3095en_US
dc.description.abstract© 2015, American Society for Microbiology. Tryptophan-rich antigens (TRAgs) are an antigen family that has been identified in human and rodent malaria parasites. TRAgs have been proposed as candidate antigens for potential vaccines. The Plasmodium vivax TRAg (PvTRAg) family includes 36 members. Each PvTRAg contains a tryptophan-rich (TR) domain in the C-terminal region. In this study, we recombinantly expressed all 36 PvTRAgs using a cell-free expression system, and, for the first time, profiled the IgG antibody responses against all PvTRAgs in the sera from 96 vivax malaria patients and 40 healthy individuals using protein microarray technology. The mean seropositive rate for all PvTRAgs was 60.3%. Among them, nine PvTRAgs were newly identified in this study and showed a seropositive rate of >50%. Five of them, PvTRAg_13, PvTRAg_15, PvTRAg_16, PvTRAg_26, and PvTRAg_29, produced higher levels of IgG antibody, even in low-endemicity countries. In addition, the results of an immunofluorescence analysis suggest that PvTRAgs are, at least in part, associated with caveola-vesicle complexes, a unique structure of P. vivax-infected erythrocytes. The mechanism of formation and the function of these abundant membrane structures are not known. Further investigation aimed at determining the functions of these proteins would lead to a better understanding of the blood-stage biology of P. vivax.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleImmunoprofiling of the tryptophan-rich antigen family in Plasmodium vivaxen_US
Appears in Collections:Scopus 2011-2015

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