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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36181
Title: Performance of binaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects
Authors: Lyda Osorio
Nick Carter
Preetam Arthur
Germana Bancone
Sowmya Gopalan
Sandeep K. Gupta
Harald Noedl
Sanjay K. Kochar
Dhanpat K. Kochar
Srivicha Krudsood
Marcus V. Lacerda
Alejandro Llanos-Cuentas
Ronnatrai Rueangweerayut
Ramadurai Srinivasan
Moritz Treiber
Jörg J. Möhrle
Justin Green
Universidad del Valle, Cali
GlaxoSmithKline plc.
Sri Ramachandra Medical College & Research Institute (Deemed University)
Shoklo Malaria Research Unit
MV Hospital and Research Centre
Medizinische Universitat Wien
Sardar Patel Medical College
University of Rajasthan
Mahidol University
Fundacao de Medicina Tropical do Amazonas
Universidad Peruana Cayetano Heredia
Mae Sot General Hospital
Clinical Development
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: American Journal of Tropical Medicine and Hygiene. Vol.92, No.1 (2015), 22-27
Abstract: Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative assay, the median G6PD activity was 8.81 U/g hemoglobin (range = 0.05-20.19), with 11 (3%) subjects identified as deficient. Sensitivity of the BinaxNOW G6PD to detect deficient subjects was 54.5% (6 of 11), and specificity was 100% (345 of 345). Room temperatures inadvertently falling outside the range required to perform the rapid test (18-25°C) together with subtlety of color change and insufficient training could partially explain the low sensitivity found. Ensuring safe use of 8-aminoquinolines depends on additional development of simple, highly sensitive G6PD deficiency diagnostic tests suitable for routine use in malaria-endemic areas.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84920557534&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36181
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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