Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36182
Title: Using Lopinavir Concentrations in Hair Samples to Assess Treatment Outcomes on Second-Line Regimens among Asian Children
Authors: Wasana Prasitsuebsai
Stephen J. Kerr
Khanh Huu Truong
Jintanat Ananworanich
Viet Chau Do
Lam Van Nguyen
Nia Kurniati
Pope Kosalaraksa
Tavitiya Sudjaritruk
Kulkanya Chokephaibulkit
Narukjaporn Thammajaruk
Thida Singtoroj
Sirinya Teeraananchai
Howard Horng
Peter Bacchetti
Monica Gandhi
Annette H. Sohn
The HIV Netherlands Australia Thailand Research Collaboration
Children's Hospital 1
Walter Reed Army Institute of Research
HJF
Children's Hospital 2
National Hospital of Pediatrics Hanoi
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Khon Kaen University
Chiang Mai University
Mahidol University
TREAT Asia/amfAR-The Foundation for AIDS Research
University of California, San Francisco
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2015
Citation: AIDS Research and Human Retroviruses. Vol.31, No.10 (2015), 1009-1014
Abstract: © 2015, Mary Ann Liebert, Inc. We conducted a prospective monitoring study to determine whether antiretroviral (ARV) levels in hair of Asian children on second-line protease inhibitor-based ARV therapy (ART) are associated with virologic failure (VF), compared to plasma drug levels and self-reported adherence. HIV-infected Asian children on second-line ART regimens were enrolled into a longitudinal cohort. Traditional adherence measures, plasma, and hair samples were collected 24 weeks after study enrollment. Hair ARV levels were determined via liquid chromatography/tandem mass spectrometry. Among 149 children on lopinavir/ritonavir-based regimens, 47% were female; the median [interquartile range (IQR)] age was 10.3 (7.9-13.3) years. The median CD4% was 26% (IQR 21.7-32.1%) and the median CD4 cell count 754 (IQR 596-1,013) cells/mm<sup>3</sup>. The median duration of lopinavir-based ART prior to week 24 of the study was 2.9 (IQR 1.6-4.2) years. Adherence was >95% in 91% (135/148) by visual analogue scale and 89% (129/145) by pill count. The median lopinavir hair concentrations were 5.43 (IQR 3.21-9.01) ng/mg in children with HIV RNA >1,000 copies/ml and 9.96 (IQR 6.51-12.31) ng/mg in children with HIV RNA <1,000 copies/ml (p = 0.003). Plasma trough and lopinavir hair concentrations were not statistically significantly correlated (Pearson's correlation coefficient 0.20; p = 0.13). Increasing lopinavir hair concentrations in quartiles were strongly associated with virologic success (odds ratios ≥4.0, overall p = 0.02), while self-reported adherence, pill count, and plasma lopinavir levels were not. Based on this first report of hair ARV concentrations and virologic outcomes in children, ARV hair concentrations, representing longer-term adherence, may be useful to identify children at risk for VF.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84941950858&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36182
ISSN: 19318405
08892229
Appears in Collections:Scopus 2011-2015

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