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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36187
Title: Biophysical approach to investigate temperature effects on protein dynamics
Authors: Yaowapa Saengpayab
Pisan Kanthang
Stefan Schreier
Charin Modchang
Narin Nuttavut
Darapond Triampo
Wannapong Triampo
Mahidol University
Rajamangala University of Technology Phra Nakhon
South Carolina Commission on Higher Education
Keywords: Materials Science
Issue Date: 1-Aug-2015
Citation: EPJ Applied Physics. Vol.71, No.3 (2015)
Abstract: © EDP Sciences, 2015. The main purpose of this work is to gain more understanding of the temperature dependence of Min protein dynamics employing spot tracking technique (STT) and biophysical characterization. We observed and confirmed the variation of protein cluster dynamics at evaluated temperatures. We found that the time MinD was retained at the cell poles played an important role in this variation. From 25 °C to 37 °C, the MinD protein oscillation period decreased 2.3 times and the anomalous dynamic exponent increased 2.4 times. The time-varied anomalous diffusion coefficient was found to be temperature dependent, which was qualitatively consistent with the prediction by Tsallis statistical mechanics. Furthermore, the average apparent effective potential depth of membrane-bound MinD protein decreased from 10.01 to 3.54 k<inf>B</inf>T. These results showed that the diffusive mode and the MinD protein cluster distribution at the cell poles were altered with temperature and this then affected the whole Min protein dynamics.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939435580&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36187
ISSN: 12860050
12860042
Appears in Collections:Scopus 2011-2015

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