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dc.contributor.authorAdhiratha Boonyasirien_US
dc.contributor.authorPeerapat Thaisiamen_US
dc.contributor.authorChairat Permpikulen_US
dc.contributor.authorTepnimitr Judaengen_US
dc.contributor.authorBordeesuda Suiwongsaen_US
dc.contributor.authorNapaporn Apiradeewajeseten_US
dc.contributor.authorTeerawan Fakthongphanen_US
dc.contributor.authorSunun Suddeeen_US
dc.contributor.authorWandee Laoagtipparosen_US
dc.contributor.authorVisanu Thamlikitkulen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationInfection Control and Hospital Epidemiology. Vol.37, No.3 (2015), 245-253en_US
dc.description.abstract© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved. Objective. To determine the effectiveness of daily bathing with 2% chlorhexidine-impregnated washcloths in preventing multidrugresistant (MDR) gram-positive bacterial colonization and bloodstream infection. methods. A randomized, open-label controlled trial was conducted in 4 medical intensive care units (ICUs) in Thailand from December 2013 to January 2015. Patients were randomized to receive cleansing with non-antimicrobial soap (control group) or 2% chlorhexidineimpregnated washcloths used to wipe the patient’s body once daily (chlorhexidine group). Swabs were taken from nares, axilla, antecubital, groin, and perianal areas on admission and on day 3, 5, 7, and 14. The 5 outcomes were (1) favorable events (all samples negative throughout ICU admission, or initially positive samples with subsequent negative samples); (2) MDR bacteria colonization-free time; (3) hospital-acquired infection; (4) length of ICU and hospital stay; (5) adverse skin reactions. results. A total of 481 patients were randomly assigned to the control group (241) or the chlorhexidine group (240). Favorable events at day 14 were observed in 34.8% of patients in the control group and 28.6% in the chlorhexidine group (P=.79). Median MDR bacteria colonizationfree times were 5 days in both groups. The incidence rate of hospital-acquired infection and the length of the ICU and hospital stay did not differ significantly between groups. The incidence of adverse skin reactions in the chlorhexidine group was 2.5%. conclusion. The effectiveness of 2% chlorhexidine-impregnated washcloths for the prevention of MDR gram-negative bacteria colonization and hospital-acquired infection in adult patients in ICU was not proven.en_US
dc.rightsMahidol Universityen_US
dc.titleEffectiveness of chlorhexidine wipes for the prevention of multidrug-resistant bacterial colonization and hospital-acquired infections in intensive care unit patients: A randomized trial in Thailanden_US
Appears in Collections:Scopus 2011-2015

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