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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36364
Title: Serum Phosphorus and Progression of CKD and Mortality: A Meta-analysis of Cohort Studies
Authors: Jingjing Da
Xinfang Xie
Myles Wolf
Sinee Disthabanchong
Jinwei Wang
Yan Zha
Jicheng Lv
Luxia Zhang
Haiyan Wang
Peking University
Guizhou Provincial People's Hospital
University of Miami Leonard M. Miller School of Medicine
Mahidol University
Keywords: Medicine
Issue Date: 1-Aug-2015
Citation: American Journal of Kidney Diseases. Vol.66, No.2 (2015), 258-265
Abstract: © 2015 National Kidney Foundation, Inc. Background Recent studies have indicated that phosphorus may play an independent pathogenic role in chronic kidney disease (CKD) progression, but some of those studies were underpowered and yielded inconsistent results. Study Design Systematic review and meta-analysis. Setting & Population Non-dialysis-dependent patients with CKD (transplant recipients were excluded). Selection Criteria for Studies Studies assessing the risk ratio of serum phosphorus level on kidney failure and mortality for non-dialysis-dependent patients with CKD published from January 1950 to June 2014 were included following systematic searching of MEDLINE, EMBASE, and the Cochrane Library. Predictor Serum phosphorus level. Outcome Kidney failure, defined as doubled serum creatinine level, 50% decline in estimated glomerular filtration rate, or end-stage kidney disease. Results In 12 cohort studies with 25,546 patients, 1,442 (8.8%) developed kidney failure and 3,089 (13.6%) died. Overall, every 1-mg/dL increase in serum phosphorus level was associated independently with increased risk of kidney failure (hazard ratio, 1.36; 95% CI, 1.20-1.55) and mortality (hazard ratio, 1.20; 95% CI, 1.05-1.37). Limitations Existence of potential residual confounding could not be excluded. Conclusions This meta-analysis suggests an independent association between serum phosphorus level and kidney failure and mortality among non-dialysis-dependent patients with CKD and suggests that large-scale randomized controlled trials should target disordered phosphorus homeostasis in CKD.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937967529&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36364
ISSN: 15236838
02726386
Appears in Collections:Scopus 2011-2015

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