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Title: Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
Authors: Tiphaine Gaillard
Kanlaya Sriprawat
Sébastien Briolant
Chirapat Wangsing
Nathalie Wurtz
Meïli Baragatti
Morgane Lavina
Aurélie Pascual
François Nosten
Bruno Pradines
Institut de recherche biomedicale des armees
Unite de Recherche sur les Maladies Infectieuses et Tropicales emergentes
HIA Sainte-Anne a Toulon
Mahidol University
Direction Inter-Armées du Service de Santé
Institut Pasteur de la Guyane
Mathematiques informatiques et statistique pour l’environnement et l’agronomie (MISTEA)
Centre National de Référence du Paludisme
University of Oxford
Keywords: Medicine
Issue Date: 1-Aug-2015
Citation: Antimicrobial Agents and Chemotherapy. Vol.59, No.8 (2015), 5080-5083
Abstract: Copyright © 2015, American Society for Microbiology. All Rights Reserved. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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