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Title: Demographic and clinical features of neuromyelitis optica: A review
Authors: L. Pandit
N. Asgari
M. Apiwattanakul
J. Palace
F. Paul
M. I. Leite
I. Kleiter
T. Chitnis
Raffaele Iorio
Jens Würfel
Friedemann Paul
Daniëlle Van Pelt
Hintzen Rogier
Thomas Tedder
Albert Saiz
Pablo Villoslada
Michael Levy
Lekha Pandit
Eric Klawiter
Brian Weinshenker
Dean Wingerchuk
Ho Jin Kim
Silvia Tenembaum
Jacqueline Palace
Maria Isabel Leite
Metha Apiwattanakul
Simon Broadley
Naraporn Prayoonwiwat
Ingo Kleiter
Kerstin Hellwig
May Han
Brenda Banwell
Katja Van Herle
Anu Jacob
Craig Hooper
Douglas Kazutoshi Sato
Ichiro Nakashima
Kazuo Fujihara
Denis Bichuetti
Orhan Aktas
Jerome De Seze
Michael Yeaman
Emmanuelle Waubant
Scott Zamvil
Jeffrey Bennett
Terry Smith
Marco Lana-Peixoto
Nasrin Asgari
Benjamin Greenberg
Olaf Stuve
K.S. Hegde Medical Academy
Syddansk Universitet
Vejle Sygehus
Prasat Neurological Institute
University of Oxford
Charité – Universitätsmedizin Berlin
St. Josef-Hospital im Katholischen Klinikum Bochum
Massachusetts General Hospital
Universita Cattolica del Sacro Cuore, Rome
Erasmus University Medical Center
Duke University School of Medicine
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Johns Hopkins University
Mayo Clinic
National Cancer Center, Gyeonggi
National Pediatric Hospital Dr. Juan P. Garrahan
Griffith University
Mahidol University
Stanford University School of Medicine
University of Pennsylvania
The Guthy-Jackson Charitable Foundation
NHS Foundation Trust
Thomas Jefferson University
Tohoku University
Universidade Federal de Sao Paulo
Heinrich Heine Universitat
CHU Strasbourg
Harbor-UCLA Medical Center
University of California, San Francisco
University of Denver
University of Michigan Medical School
University of Minas Gerais Medical School
UT Southwestern Medical Center
Yale University School of Medicine
Keywords: Medicine
Issue Date: 6-Jun-2015
Citation: Multiple Sclerosis Journal. Vol.21, No.7 (2015), 845-853
Abstract: © The Author(s), 2015. The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.
ISSN: 14770970
Appears in Collections:Scopus 2011-2015

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