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Title: Connectivity and circuitry in a dish versus in a brain
Authors: Vorapin Chinchalongporn
Peter Koppensteiner
Deborah Prè
Wipawan Thangnipon
Leonilda Bilo
Ottavio Arancio
Columbia University in the City of New York
Mahidol University
Medizinische Universitat Wien
Universita degli Studi di Napoli Federico II
Keywords: Medicine
Issue Date: 4-Jun-2015
Citation: Alzheimer's Research and Therapy. Vol.7, No.1 (2015)
Abstract: © 2015 Chinchalongporn et al.; licensee BioMed Central. In order to understand and find therapeutic strategies for neurological disorders, disease models that recapitulate the connectivity and circuitry of patients' brain are needed. Owing to many limitations of animal disease models, in vitro neuronal models using patient-derived stem cells are currently being developed. However, prior to employing neurons as a model in a dish, they need to be evaluated for their electrophysiological properties, including both passive and active membrane properties, dynamics of neurotransmitter release, and capacity to undergo synaptic plasticity. In this review, we survey recent attempts to study these issues in human induced pluripotent stem cell-derived neurons. Although progress has been made, there are still many hurdles to overcome before human induced pluripotent stem cell-derived neurons can fully recapitulate all of the above physiological properties of adult mature neurons. Moreover, proper integration of neurons into pre-existing circuitry still needs to be achieved. Nevertheless, in vitro neuronal stem cell-derived models hold great promise for clinical application in neurological diseases in the future.
ISSN: 17589193
Appears in Collections:Scopus 2011-2015

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