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Title: Consensus on the development of vaccines against naturally acquired melioidosis
Authors: Direk Limmathurotsakul
Simon G.P. Funnell
Alfredo G. Torres
Lisa A. Morici
Paul J. Brett
Susanna Dunachie
Timothy Atkins
Daniel M. Altmann
Gregory Bancroft
Sharon J. Peacock
Mahidol University
Public Health England
UT Medical Branch at Galveston
Tulane University School of Medicine
University of South Alabama
University of Oxford
Defence Science and Technology Laboratory
Imperial College London
London School of Hygiene & Tropical Medicine
University of Cambridge
Keywords: Medicine
Issue Date: 1-Jun-2015
Citation: Emerging Infectious Diseases. Vol.21, No.6 (2015), e1-e7
Abstract: © 2015, Marmara University. All rights reserved. Several candidates for a vaccine against Burkholderia pseudomallei, the causal bacterium of melioidosis, have been developed, and a rational approach is now needed to select and advance candidates for testing in relevant nonhuman primate models and in human clinical trials. Development of such a vaccine was the topic of a meeting in the United Kingdom in March 2014 attended by international candidate vaccine developers, researchers, and government health officials. The focus of the meeting was advancement of vaccines for prevention of natural infection, rather than for protection from the organism’s known potential for use as a biological weapon. A direct comparison of candidate vaccines in well-characterized mouse models was proposed. Knowledge gaps requiring further research were identified. Recommendations were made to accelerate the development of an effective vaccine against melioidosis.
ISSN: 10806059
Appears in Collections:Scopus 2011-2015

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