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dc.contributor.authorFrancesco Pellicciaen_US
dc.contributor.authorGuido Parodien_US
dc.contributor.authorCesare Grecoen_US
dc.contributor.authorDavid Antoniuccien_US
dc.contributor.authorRoman Brenneren_US
dc.contributor.authorEduardo Bossoneen_US
dc.contributor.authorLuca Cacciottien_US
dc.contributor.authorAlessandro Capuccien_US
dc.contributor.authorRodolfo Citroen_US
dc.contributor.authorClément Delmasen_US
dc.contributor.authorFederico Guerraen_US
dc.contributor.authorCostin N. Ionescuen_US
dc.contributor.authorOlivier Lairezen_US
dc.contributor.authorMaiteder Larrauri-Reyesen_US
dc.contributor.authorPil Hyung Leeen_US
dc.contributor.authorNicolas Mansencalen_US
dc.contributor.authorGiuseppe Marazzien_US
dc.contributor.authorChristos G. Mihosen_US
dc.contributor.authorOlivier Morelen_US
dc.contributor.authorHolger M. Nefen_US
dc.contributor.authorIvan J. Nunez Gilen_US
dc.contributor.authorIlaria Passaseoen_US
dc.contributor.authorAndres M. Pinedaen_US
dc.contributor.authorGiuseppe Rosanoen_US
dc.contributor.authorOrlando Santanaen_US
dc.contributor.authorFranziska Schnecken_US
dc.contributor.authorBong Gun Songen_US
dc.contributor.authorJae Kwan Songen_US
dc.contributor.authorAndrew W. Tehen_US
dc.contributor.authorPatompong Ungpraserten_US
dc.contributor.authorAlberto Valbusaen_US
dc.contributor.authorAndreas Wahlen_US
dc.contributor.authorTetsuro Yoshidaen_US
dc.contributor.authorCarlo Gaudioen_US
dc.contributor.authorJuan Carlos Kaskien_US
dc.contributor.otherUniversita degli Studi di Roma La Sapienzaen_US
dc.contributor.otherAzienda Ospedaliera Careggien_US
dc.contributor.otherKantonsspital Oltenen_US
dc.contributor.otherUniversity Hospital San Giovanni di Dio e Ruggi d'Aragonaen_US
dc.contributor.otherOspedale Madre G. Vanninien_US
dc.contributor.otherUniversita Politecnica delle Marcheen_US
dc.contributor.otherHopital de Rangueilen_US
dc.contributor.otherYale Universityen_US
dc.contributor.otherMount Sinai Medical Center Miami Beachen_US
dc.contributor.otherUniversity of Ulsan, College of Medicineen_US
dc.contributor.otherUniversite de Versailles Saint-Quentin-en-Yvelinesen_US
dc.contributor.otherIRCCS San Raffaele Pisanaen_US
dc.contributor.otherPôle d'Activité Medico-chirurgicale Cardiovasculaireen_US
dc.contributor.otherJustus Liebig University Giessenen_US
dc.contributor.otherHospital Clinico San Carlos de Madriden_US
dc.contributor.otherSt George's University of Londonen_US
dc.contributor.otherKonkuk University Hospitalen_US
dc.contributor.otherMonash Universityen_US
dc.contributor.otherAustin Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherIRCCS Istituto Giannina Gaslini - Ospedale Pediatricoen_US
dc.contributor.otherUniversitatsSpital Bernen_US
dc.contributor.otherOnga Hospitalen_US
dc.identifier.citationAmerican Journal of Medicine. Vol.128, No.6 (2015), 654.e11-654.e19en_US
dc.description.abstract© 2015 Elsevier Inc. All rights reserved. Background To identify predisposing factors that can result in the onset of takotsubo syndrome, we performed an international, collaborative systematic review focusing on clinical characteristics and comorbidities of patients with takotsubo syndrome. Methods We searched and reviewed cited references up to August 2013 to identify relevant studies. Corresponding authors of selected studies were contacted and asked to provide additional quantitative details. Data from each study were extracted by 2 independent reviewers. The cumulative prevalence of presenting features and comorbidities was assessed. Nineteen studies whose authors sent the requested information were included in the systematic review, with a total of 1109 patients (951 women; mean age, 59-76 years). Evaluation of risk factors showed that obesity was present in 17% of patients (range, 2%-48%), hypertension in 54% (range, 27%-83%), dyslipidemia in 32% (range, 7%-59%), diabetes in 17% (range, 4%-34%), and smoking in 22% (range, 6%-49%). Emotional stressors preceded takotsubo syndrome in 39% of patients and physical stressors in 35%. The most common comorbidities were psychological disorders (24%; range, 0-49%), pulmonary diseases (15%; range, 0-22%), and malignancies (10%; range, 4%-29%). Other common associated disorders were neurologic diseases (7%; range, 0-22%), chronic kidney disease (7%; range, 2%-27%), and thyroid diseases (6%; range, 0-37%). Conclusions Patients with takotsubo syndrome have a relevant prevalence of cardiovascular risk factors and associated comorbidities. Such of associations needs to be evaluated in further studies.en_US
dc.rightsMahidol Universityen_US
dc.titleComorbidities frequency in takotsubo syndrome: An international collaborative systematic review including 1109 patientsen_US
Appears in Collections:Scopus 2011-2015

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