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Title: Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker
Authors: Neelima Mishra
Surendra Kumar Prajapati
Kamlesh Kaitholia
Ram Suresh Bharti
Bina Srivastava
Sobhan Phookan
Anupkumar R. Anvikar
Vas Dev
Gagan Singh Sonal
Akshay Chandra Dhariwal
Nicholas J. White
Neena Valecha
National Institute of Malaria Research India
Ministry of Health and Family Welfare
Mahidol University
Nuffield Department of Clinical Medicine
Keywords: Medicine
Issue Date: 1-May-2015
Citation: Antimicrobial Agents and Chemotherapy. Vol.59, No.5 (2015), 2548-2553
Abstract: Copyright © 2015, American Society for Microbiology. All Rights Reserved. Malaria treatment in Southeast Asia is threatened with the emergence of artemisinin-resistant Plasmodium falciparum. Genome association studies have strongly linked a locus on P. falciparum chromosome 13 to artemisinin resistance, and recently, mutations in the kelch13 propeller region (Pfk-13) were strongly linked to resistance. To date, this information has not been shown in Indian samples. Pfk-13 mutations were assessed in samples from efficacy studies of artemisinin combination treatments in India. Samples were PCR amplified and sequenced from codon 427 to 727. Out of 384 samples, nonsynonymous mutations in the propeller region were found in four patients from the northeastern states, but their presence did not correlate with ACT treatment failures. This is the first report of Pfk-13 point mutations from India. Further phenotyping and genotyping studies are required to assess the status of artemisinin resistance in this region.
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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