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Title: Hypomagnesaemia linked to depression: A systematic review and meta-analysis
Authors: W. Cheungpasitporn
C. Thongprayoon
M. A. Mao
N. Srivali
P. Ungprasert
N. Varothai
A. Sanguankeo
W. Kittanamongkolchai
S. B. Erickson
Mayo Clinic
Tufts Medical Center
Bassett Medical Center
Mahidol University
Keywords: Medicine
Issue Date: 1-Apr-2015
Citation: Internal Medicine Journal. Vol.45, No.4 (2015), 436-440
Abstract: © 2015 Royal Australasian College of Physicians. Background: The reported risk of depression in patients with hypomagnesaemia is controversial. Aim: The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. Methods: A literature search was performed using MEDLINE, EMBASE, Cochrane Database and from inception through October 2014. Studies that reported odds ratios, relative risks or hazard ratios comparing the risk of depression in patients with hypomagnesaemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Six observational studies (three cohort studies, two cross-sectional studies and a case-control study) with a total of 19137 patients were identified and included in the data analysis. The pooled RR of depression in patients with hypomagnesaemia was 1.34 (95% CI, 1.01-1.79, I2= 33%). The association between depression and hypomagnesaemia was marginally insignificant after the sensitivity analysis including only cohort and case-control studies, with a pooled RR of 1.38 (95% CI, 0.92-2.07, I2= 24%). Conclusion: Our study demonstrates a potential association between hypomagnesaemia and depression. Further studies assessing the benefits of treatment of hypomagnesaemia in patients with depression are needed.
ISSN: 14455994
Appears in Collections:Scopus 2011-2015

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