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dc.contributor.authorLiesbeth M. Kageren_US
dc.contributor.authorDana C. Bloken_US
dc.contributor.authorIvar O. Ledeen_US
dc.contributor.authorWahid Rahmanen_US
dc.contributor.authorRumana Afrozen_US
dc.contributor.authorPaul Bresseren_US
dc.contributor.authorJaring S. van der Zeeen_US
dc.contributor.authorAniruddha Ghoseen_US
dc.contributor.authorCaroline E. Visseren_US
dc.contributor.authorMenno D. de Jongen_US
dc.contributor.authorMichael W. Tancken_US
dc.contributor.authorAbu Shahed M. Zaheden_US
dc.contributor.authorKhan Mashrequl Alamen_US
dc.contributor.authorMahtabuddin Hassanen_US
dc.contributor.authorAhmed Hossainen_US
dc.contributor.authorRene Lutteren_US
dc.contributor.authorCornelis van t. Veeren_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorJoost C.M. Meijersen_US
dc.contributor.authorTom van der Pollen_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherDepartment of Pulmonologyen_US
dc.contributor.otherChittagong Medical College Hospitalen_US
dc.contributor.otherChittagong Medical Collegeen_US
dc.contributor.otherChest Disease Clinic Chittagong (CDCC)en_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.identifier.citationJournal of Infection. Vol.70, No.4 (2015), 324-334en_US
dc.description.abstract© 2014 The British Infection Association. Objectives: Human tuberculosis (TB) remains an important cause of death globally. Bangladesh is one of the most affected countries. We aimed to investigate the impact of pulmonary TB on pro- and anticoagulant mechanisms. Methods: This prospective study was conducted in Chittagong, Bangladesh. We performed an in-depth analysis of coagulation activation and inhibition in plasma obtained from 64 patients with primary lung TB and 11 patients with recurrent lung TB and compared these with 37 healthy controls. Additionally, in nine patients coagulation activation was studied in bronchoalveolar lavage fluid (BALF) harvested from the site of infection and compared with BALF from a contralateral unaffected lung subsegment. Results: Relative to uninfected controls, primary and recurrent TB were associated with a systemic net procoagulant state, as indicated by enhanced activation of coagulation (elevated plasma levels of thrombin-antithrombin complexes, D-dimer and fibrinogen) together with impaired anticoagulant mechanisms (reduced plasma levels of antithrombin, protein C activity, free protein S, and protein C inhibitor). Activation of coagulation did not correlate with plasma concentrations of established TB biomarkers. Coagulation activation could not be detected at the primary site of infection in a subset of TB patients. Conclusions: Pulmonary TB is associated with a systemic hypercoagulable state.en_US
dc.rightsMahidol Universityen_US
dc.titlePulmonary tuberculosis induces a systemic hypercoagulable stateen_US
Appears in Collections:Scopus 2011-2015

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