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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36486
Title: Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes
Authors: Hataikarn Nimitphong
Chanika Sritara
La Or Chailurkit
Suwannee Chanprasertyothin
Wipa Ratanachaiwong
Piyamitr Sritara
Boonsong Ongphiphadhanakul
Mahidol University
Health Office
Keywords: Medicine
Issue Date: 24-Mar-2015
Citation: Nutrition Journal. Vol.14, No.1 (2015)
Abstract: © 2015 Nimitphong et al.; licensee BioMed Central. Background: Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures. Emerging data suggest that fetuin-A may be involved in bone metabolism. We aimed to investigate the influence of DBP gene polymorphism on the relationship of vitamin D status and fetuin-A levels to BMD and bone markers. Methods: This cross-sectional study was part of a health survey of employees of the Electricity Generating Authority of Thailand (1,734 healthy subjects, 72% male). Fasting blood samples were assayed for 25(OH)D, fetuin-A, N-terminal propeptides of type 1 procollagen (P1NP), C-terminal cross-linking telopeptides of type I collagen (CTx-I), and DBP rs2282679 genotypes. L1-L4 lumbar spine and femoral BMD were measured using dual-energy X-ray absorptiometry. Results: The DBP rs2282679 genotype distribution conformed to the Hardy-Weinberg equilibrium. There were no correlations between 25(OH)D levels and BMD and bone markers. But a trend of positive correlation was observed for the DBP genotypes with total hip BMD, and for the interaction between 25(OH)D and DBP genotypes with BMD at all femoral sites. We further analyzed data according to DBP genotypes. Only in subjects with the AA (common) genotype, 25(OH)D levels were positively related to BMD and bone markers, while fetuin-A was negatively related to total hip BMD, independently of age, gender and BMI. Conclusions: The interaction between vitamin D status, as measured by circulating 25(OH)D and DBP rs2282679 genotypes, modified the association between 25(OH)D and BMD and bone markers. Differences in DBP genotypes additionally influenced the correlation of fetuin-A levels with femoral BMD.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84926475545&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36486
ISSN: 14752891
Appears in Collections:Scopus 2011-2015

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