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Title: Emerging clinical applications of selected biomarkers in melanoma
Authors: Michael T. Tetzlaff
Carlos A. Torres-Cabala
Penvadee Pattanaprichakul
Ronald P. Rapini
Victor G. Prieto
Jonathan L. Curry
University of Texas MD Anderson Cancer Center
Mahidol University
Keywords: Medicine
Issue Date: 30-Jan-2015
Citation: Clinical, Cosmetic and Investigational Dermatology. Vol.8, (2015), 35-46
Abstract: © 2015 Tetzlaff et al. Melanoma is a lethal skin disease with a mostly predictable clinical course according to a known constellation of clinical and pathologic features. The distinction of melanoma from benign melanocytic nevus is typically unequivocol; however, there is a subset of tumors known for its diagnostic challenges, development of late metastases, and difficulties in treatment. Several melanocytic tissue biomarkers are available that can facilitate the histopathologic interpretation of melanoma as well as provide insight into the biologic potential and mutational status of this disease. This review describes the clinical application of some of these established and emerging tissue biomarkers available to assess melanocytic differentiation, vascular invasion, mitotic capacity, and mutation status. The selected tissue biomarkers in this review include MiTF, Sox10, D2-40, PHH3, H3KT (anti-H3K79me3T80ph), anti-BRAFV600E, and anti-BAP-1.
ISSN: 11787015
Appears in Collections:Scopus 2011-2015

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