Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36526
Title: Primary Cutaneous NK/T-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma A cellular lineage and clinicopathologic study of 60 patients from Asia
Authors: Katsuyoshi Takata
Min Eui Hong
Panitta Sitthinamsuwan
Florence Loong
Soo Yong Tan
Jau Yu Liau
Pin Pen Hsieh
Siok Bian Ng
Sheau Fang Yang
Tawatchai Pongpruttipan
Sanya Sukpanichnant
Yok Lam Kwong
Young Hyeh Ko
Yung Tsu Cho
Wee Joo Chng
Takashi Matsushita
Tadashi Yoshino
Shih Sung Chuang
Okayama University Medical School
Kanazawa University School of Medicine
Samsung Medical Center
Samsung Medical Center, Sungkyunkwan University
Mahidol University
Departments of Pathology
Queen Mary Hospital Hong Kong
Singapore General Hospital
National University Health System
Cancer Science Institute of Singapore
National Taiwan University Hospital
Taipei Medical University
Veterans General Hospital-Kaohsiung Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Keywords: Medicine
Issue Date: 20-Jan-2015
Citation: American Journal of Surgical Pathology. Vol.39, No.1 (2015), 1-12
Abstract: Copyright © 2014 by Lippincott Williams & Wilkins. Primary cutaneous, extranodal natural killer/T-cell lymphoma, nasal type (PC-ENKTL), is a rare Epstein-Barr virus (EBV)-associated neoplasm with poorly defined clinicopathologic features. We performed a multinational retrospective study of PC-ENKTL and CD56-positive EBVnegative peripheral T-cell lymphoma (PC-CD56+PTCL) in Asia in an attempt to elucidate their clinicopathologic features. Using immunohistochemistry for T-cell receptors (TCRs), in situ hybridization for EBV, and TCR gene rearrangement, we classified 60 tumors into 51 with PC-ENKTL (20 of NK-cell, 17 T-cell, and 14 indeterminate lineages) and 9 with PCCD56+ PTCL. Tumors of T-cell origin accounted for 46% of PC-ENKTLs with half of these cases being TCR-silent. As compared with T-lineage tumors, PC-ENKTLs of NK-cell lineage had more frequent involvement of regional lymph nodes and more frequently CD8-negative and CD56-positive. Cases of PC-ENKTL showed more frequent tumor necrosis, younger age, and a higher frequency of CD16 and CD30 expression than cases of PC-CD56+PTCL. CD56-positive T-lineage PCENKTL tumors (n=8) had more localized disease in the TNM (tumor-node-metastasis) staging and were more often of gd Tcell origin compared with cases of PC-CD56+PTCL (n=9). PC-ENKTLs and PC-CD56+PTCLs were equally aggressive, with a 5-year overall survival rate of 25%. Tumor necrosis and CD16 expression may serve as useful surrogates for differentiating PC-ENKTL from PC-CD56+PTCL. A single lesion, an elevated lactate dehydrogenase level, and the presence of B symptoms were independent poor prognostic factors for PCENKTL in multivariate analysis. Further studies with more cases are warranted to delineate the clinicopathologic features and significance of EBV in these rare lymphomas.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84919352045&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36526
ISSN: 15320979
01475185
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.