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Title: Economic evaluation of 3-drug antiretroviral regimens for the prevention of mother-to-child HIV transmission in Thailand
Authors: Pitsaphun Werayingyong
Nittaya Phanuphak
Kulkunya Chokephaibulkit
Sripen Tantivess
Nareeluk Kullert
Kakanang Tosanguan
Rukmanee Butchon
Nipunporn Voramongkol
Sarawut Boonsuk
Songyot Pilasant
Wantanee Kulpeng
Y. Teerawattananon
Thailand Ministry of Public Health
Thai Red Cross AIDS Research Centre
Mahidol University
Benjalak Hospital
Keywords: Medicine
Issue Date: 1-Jan-2015
Citation: Asia-Pacific Journal of Public Health. Vol.27, No.2 (2015), NP866-NP876
Abstract: © 2013 APJPH. The current program for prevention of mother-to-child HIV transmission in Thailand recommends a 2-drugs regimen for HIV-infected pregnant women with a CD4 count >200 cells/mm3. This study assesses the value for money of 3 antiretroviral drugs compared with zidovudine (AZT)+single-dose nevirapine (sd-NVP). A decision tree was constructed to predict costs and outcomes using the governmental perspective for assessing cost-effectiveness of 3-drug regimens: (1) AZT, lamivudine, and efavirenz and (2) AZT, 3TC, and lopinavir/ritonavir, in comparison with the current protocol, AZT+sd-NVP. The 3-drug antiretroviral regimens yield lower costs and better health outcomes compared with AZT+sd-NVP. Although these 3-drug regimens offer higher program costs and health care costs for premature birth, they save money significantly in regard to pediatric HIV treatment and treatment costs for drug resistance in mothers. The 3-drug regimens are cost-saving interventions. The findings from this study were used to support a policy change in the national recommendation.
ISSN: 10105395
Appears in Collections:Scopus 2011-2015

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