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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/36818
Title: Cost-utility analysis of adjuvant chemotherapy in patients with stage III colon cancer in Thailand
Authors: Panattharin Lerdkiattikorn
Usa Chaikledkaew
Wirote Lausoontornsiri
Somjin Chindavijak
Thirawud Khuhaprema
Narisa Tantai
Yot Teerawattananon
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
Thailand Ministry of Public Health
National Cancer Institute Thailand
Keywords: Medicine
Issue Date: 1-Jan-2015
Citation: Expert Review of Pharmacoeconomics and Outcomes Research. Vol.15, No.4 (2015), 687-700
Abstract: © 2014 Informa UK Ltd. Background: In Thailand, there has been no economic evaluation study of adjuvant chemotherapy for stage III colon cancer patients after resection. Objective: This study aims to evaluate the cost-utility of all chemotherapy regimens currently used in Thailand compared with the adjuvant 5-fluorouracil/leucovorin (5-FU/LV) plus capecitabine as the first-line therapy for metastatic disease in patients with stage III colon cancer after resection. Methods: A cost-utility analysis was performed to estimate the relevant lifetime costs and health outcomes of chemotherapy regimens based on a societal perspective using a Markov model. Results: The results suggested that the adjuvant 5-FU/LV plus capecitabine as the first-line therapy for metastatic disease would be the most cost-effective chemotherapy. Conclusions: The adjuvant FOLFOX and FOLFIRI as the first-line treatment for metastatic disease would be cost-effective with an incremental cost-effectiveness ratio of 299,365 Thai baht per QALY gained based on a societal perspective if both prices of FOLFOX and FOLFIRI were decreased by 40%.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84945918065&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/36818
ISSN: 17448379
14737167
Appears in Collections:Scopus 2011-2015

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