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|Title:||Cost-utility analysis of adjuvant chemotherapy in patients with stage III colon cancer in Thailand|
Faculty of Medicine, Siriraj Hospital, Mahidol University
Thailand Ministry of Public Health
National Cancer Institute Thailand
|Citation:||Expert Review of Pharmacoeconomics and Outcomes Research. Vol.15, No.4 (2015), 687-700|
|Abstract:||© 2014 Informa UK Ltd. Background: In Thailand, there has been no economic evaluation study of adjuvant chemotherapy for stage III colon cancer patients after resection. Objective: This study aims to evaluate the cost-utility of all chemotherapy regimens currently used in Thailand compared with the adjuvant 5-fluorouracil/leucovorin (5-FU/LV) plus capecitabine as the first-line therapy for metastatic disease in patients with stage III colon cancer after resection. Methods: A cost-utility analysis was performed to estimate the relevant lifetime costs and health outcomes of chemotherapy regimens based on a societal perspective using a Markov model. Results: The results suggested that the adjuvant 5-FU/LV plus capecitabine as the first-line therapy for metastatic disease would be the most cost-effective chemotherapy. Conclusions: The adjuvant FOLFOX and FOLFIRI as the first-line treatment for metastatic disease would be cost-effective with an incremental cost-effectiveness ratio of 299,365 Thai baht per QALY gained based on a societal perspective if both prices of FOLFOX and FOLFIRI were decreased by 40%.|
|Appears in Collections:||Scopus 2011-2015|
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