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Title: Pulmonary and Systemic Pharmacokinetics of Colistin Following a Single Dose of Nebulized Colistimethate in Mechanically Ventilated Neonates
Authors: Narongsak Nakwan
Pichaya Lertpichaluk
Kulkanya Chokephaibulkit
Paola Villani
Mario Regazzi
Roberto Imberti
Hat Yai Hospital
Mahidol University
Fondazione IRCCS Policlinico San Matteo
Keywords: Medicine
Issue Date: 1-Jan-2015
Citation: Pediatric Infectious Disease Journal. Vol.34, No.9 (2015), 961-963
Abstract: Copyright © 2015 Wolters Kluwer Health, Inc. The purpose of this study was to evaluate the pulmonary and systemic pharmacokinetics of colistin following a single dose of nebulized colistimethate sodium (CMS) in mechanically ventilated neonates. We administered a single dose of nebulized CMS (approximately 120,000 IU/kg of CMS, equivalent to 4 mg/kg colistin base activity) to 6 ventilated neonates with ventilator-associated pneumonia. The median gestational age was 39 weeks (range, 32-39 weeks). Mean (±SD) tracheal aspirate colistin maximum concentration (C<inf>max</inf>), area under the concentration-time curve (AUC<inf>0-24</inf>) and t<inf>1/2</inf> were 24.0 ± 8.2 μg/mL, 147.6 ± 53.5 μg·hours/mL and 9.8 ± 5.5 hours, respectively. The plasma concentrations of colistin were low. In neonates, a single nebulized dose of CMS (120,000 IU) resulted in high local concentrations for at least 12 hours and low systemic concentrations of colistin. Twice daily nebulization might be more appropriate.
ISSN: 15320987
Appears in Collections:Scopus 2011-2015

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