Please use this identifier to cite or link to this item:
|Title:||Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine|
King Mongkut's University of Technology North Bangkok
Faculty of Medicine, Siriraj Hospital, Mahidol University
|Citation:||Evidence-based Complementary and Alternative Medicine. Vol.2015, (2015)|
|Abstract:||© 2015 Jutamas Saengsai et al. Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.|
|Appears in Collections:||Scopus 2011-2015|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.