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Title: Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine
Authors: Jutamas Saengsai
Sumonthip Kongtunjanphuk
Nuttawan Yoswatthana
Tanawan Kummalue
Weena Jiratchariyakul
Mahidol University
King Mongkut's University of Technology North Bangkok
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2015
Citation: Evidence-based Complementary and Alternative Medicine. Vol.2015, (2015)
Abstract: © 2015 Jutamas Saengsai et al. Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.
ISSN: 17414288
Appears in Collections:Scopus 2011-2015

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