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Title: Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
Authors: Amaraporn Wongrakpanich
Imali A. Mudunkotuwa
Sean M. Geary
Angie S. Morris
Kranti A. Mapuskar
Douglas R. Spitz
Vicki H. Grassian
Aliasger K. Salem
University of Iowa
Mahidol University
University of Iowa Carver College of Medicine
Scripps Institution of Oceanography
Keywords: Environmental Science;Materials Science
Issue Date: 1-Jan-2016
Citation: Environmental Science: Nano. Vol.3, No.2 (2016), 365-374
Abstract: © 2016 The Royal Society of Chemistry. The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+and causing a differential impact on cytotoxicity.
ISSN: 20518161
Appears in Collections:Scopus 2016-2017

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