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dc.contributor.authorDavid A. Cabralen_US
dc.contributor.authorDebra L. Canteren_US
dc.contributor.authorEyal Muscalen_US
dc.contributor.authorKabita Nandaen_US
dc.contributor.authorDawn M. Wahezien_US
dc.contributor.authorSteven J. Spaldingen_US
dc.contributor.authorMarinka Twilten_US
dc.contributor.authorSusanne M. Benseleren_US
dc.contributor.authorSarah Campilloen_US
dc.contributor.authorSirirat Charuvanijen_US
dc.contributor.authorPaul Danceyen_US
dc.contributor.authorBarbara A. Eberharden_US
dc.contributor.authorMelissa E. Elderen_US
dc.contributor.authorAimee Hershen_US
dc.contributor.authorGloria C. Higginsen_US
dc.contributor.authorAdam M. Huberen_US
dc.contributor.authorRaju Khubchandanien_US
dc.contributor.authorSusan Kimen_US
dc.contributor.authorMarisa Klein-Gitelmanen_US
dc.contributor.authorMikhail M. Kostiken_US
dc.contributor.authorErica F. Lawsonen_US
dc.contributor.authorTzielan Leeen_US
dc.contributor.authorJoanna M. Lubienieckaen_US
dc.contributor.authorDeborah McCurdyen_US
dc.contributor.authorLakshmi N. Moorthyen_US
dc.contributor.authorKimberly A. Morishitaen_US
dc.contributor.authorSusan M. Nielsenen_US
dc.contributor.authorKathleen M. O'Neilen_US
dc.contributor.authorAndreas Reiffen_US
dc.contributor.authorGoran Risticen_US
dc.contributor.authorAngela B. Robinsonen_US
dc.contributor.authorAngelyne Sarmientoen_US
dc.contributor.authorSusan Shenoien_US
dc.contributor.authorMary B. Tothen_US
dc.contributor.authorHeather A. Van Materen_US
dc.contributor.authorLinda Wagner-Weineren_US
dc.contributor.authorJennifer E. Weissen_US
dc.contributor.authorAndrew J. Whiteen_US
dc.contributor.authorRae S.M. Yeungen_US
dc.contributor.authorDavid A. Cabralen_US
dc.contributor.authorAngelyne Sarmientoen_US
dc.contributor.authorQun Yangen_US
dc.contributor.authorVictor Espinosaen_US
dc.contributor.authorJoanna Lubienieckien_US
dc.contributor.authorJaime Guzmanen_US
dc.contributor.authorKristin Houghtonen_US
dc.contributor.authorRoss Pettyen_US
dc.contributor.authorLori Tuckeren_US
dc.contributor.authorMary B. Tothen_US
dc.contributor.authorSusanne Benseleren_US
dc.contributor.authorMarinka Twilten_US
dc.contributor.authorMichael Beresforden_US
dc.contributor.authorEileen Baildamen_US
dc.contributor.authorMarisa Klein-Gitelmanen_US
dc.contributor.authorMichael Milleren_US
dc.contributor.authorMegan Curranen_US
dc.contributor.authorTaunton Southwooden_US
dc.contributor.authorRaju Khubchandanien_US
dc.contributor.authorNorman T. Ilowiteen_US
dc.contributor.authorDawn M. Wahezien_US
dc.contributor.authorSusan Kimen_US
dc.contributor.authorFatma Dedeogluen_US
dc.contributor.authorRobert Fuhlbriggeen_US
dc.contributor.authorMelissa Hazenen_US
dc.contributor.authorMary Beth Sonen_US
dc.contributor.authorRobert Sundelen_US
dc.contributor.authorAndreas Reiffen_US
dc.contributor.authorDiane Brownen_US
dc.contributor.authorKatherine Marzanen_US
dc.contributor.authorAnusha Ramanathanen_US
dc.contributor.authorBracha Shahamen_US
dc.contributor.authorCiaran Duffyen_US
dc.contributor.authorMatthew Adamsen_US
dc.contributor.authorRudolf Valentinien_US
dc.contributor.authorMargalit Rosenkranzen_US
dc.contributor.authorDaniel Kietzen_US
dc.contributor.authorElaine Cassidyen_US
dc.contributor.authorKathryn Toroken_US
dc.contributor.authorMara Beckeren_US
dc.contributor.authorLawrence K. Jungen_US
dc.contributor.authorSteven Spaldingen_US
dc.contributor.authorAndrew Zeften_US
dc.contributor.authorAnne Eberharden_US
dc.contributor.authorBett Gottlieben_US
dc.contributor.authorCagri Toruneren_US
dc.contributor.authorLinda Wagner-Weineren_US
dc.contributor.authorKaren Onelen_US
dc.contributor.authorCharles Spenceren_US
dc.contributor.authorDeidre De Ranierien_US
dc.contributor.authorMelissa Tesheren_US
dc.contributor.authorAndrew Eichenfielden_US
dc.contributor.authorLisa Imundoen_US
dc.contributor.authorHeather Van Materen_US
dc.contributor.authorC. Egla Rabinovichen_US
dc.contributor.authorLaura Schanbergen_US
dc.contributor.authorJeffery Dvergstenen_US
dc.contributor.authorMark Friswellen_US
dc.contributor.authorRae Yeungen_US
dc.contributor.authorBrian Feldmanen_US
dc.contributor.otherBC Children's Hospitalen_US
dc.contributor.otherTexas Children's Hospitalen_US
dc.contributor.otherChildren's Hospital and Regional Medical Centeren_US
dc.contributor.otherThe Childen's Hospital at Montefioreen_US
dc.contributor.otherCleveland Clinic Foundationen_US
dc.contributor.otherAlberta Children's Hospitalen_US
dc.contributor.otherCentre universitaire de santé McGill, Hôpital de Montreal Pour Enfantsen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNew Janeway Childrens Health and Rehabilitation Centreen_US
dc.contributor.otherChildren's Medical Centeren_US
dc.contributor.otherUniversity of Floridaen_US
dc.contributor.otherUniversity of Utahen_US
dc.contributor.otherChildren's Hospital Columbusen_US
dc.contributor.otherIWK Health Centreen_US
dc.contributor.otherBreach Candy Hospitalen_US
dc.contributor.otherChildren's Hospital Bostonen_US
dc.contributor.otherAnn & Robert H. Lurie Children's Hospital of Chicagoen_US
dc.contributor.otherSaint Petersburg State Pediatric Medical Universityen_US
dc.contributor.otherUniversity of California, San Franciscoen_US
dc.contributor.otherStanford University School of Medicineen_US
dc.contributor.otherSimon Fraser Universityen_US
dc.contributor.otherUniversity of California, Los Angelesen_US
dc.contributor.otherRutgers Robert Wood Johnson Medical Schoolen_US
dc.contributor.otherRigshospitaleten_US
dc.contributor.otherRiley Children's Hospitalen_US
dc.contributor.otherChildren's Hospital Los Angelesen_US
dc.contributor.otherMother and Child Health Care Institute of Serbiaen_US
dc.contributor.otherRainbow Babies and Children's Hosp.en_US
dc.contributor.otherAkron Children's Hospitalen_US
dc.contributor.otherDuke University Medical Centeren_US
dc.contributor.otherUniversity of Chicagoen_US
dc.contributor.otherThe Joseph M. Sanzari Children's Hospitalen_US
dc.contributor.otherSt. Louis Children's Hospitalen_US
dc.contributor.otherHospital for Sick Children University of Torontoen_US
dc.date.accessioned2018-12-11T02:58:06Z
dc.date.accessioned2019-03-14T08:01:37Z-
dc.date.available2018-12-11T02:58:06Z
dc.date.available2019-03-14T08:01:37Z-
dc.date.issued2016-10-01en_US
dc.identifier.citationArthritis and Rheumatology. Vol.68, No.10 (2016), 2514-2526en_US
dc.identifier.issn23265205en_US
dc.identifier.issn23265191en_US
dc.identifier.other2-s2.0-84988844556en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988844556&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/40724-
dc.description.abstract© 2016, American College of Rheumatology Objective: To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (GPA). Methods: The European Medicines Agency (EMA) classification algorithm was applied by computation to categorical data from patients recruited to the ARChiVe (A Registry for Childhood Vasculitis: e-entry) cohort, with the data censored to November 2015. The EMA algorithm was used to uniquely distinguish children with MPA from children with GPA, whose diagnoses had been classified according to both adult- and pediatric-specific criteria. Descriptive statistics were used for comparisons. Results: In total, 231 of 440 patients (64% female) fulfilled the classification criteria for either MPA (n = 48) or GPA (n = 183). The median time to diagnosis was 1.6 months in the MPA group and 2.1 months in the GPA group (ranging to 39 and 73 months, respectively). Patients with MPA were significantly younger than those with GPA (median age 11 years versus 14 years). Constitutional features were equally common between the groups. In patients with MPA compared to those with GPA, pulmonary manifestations were less frequent (44% versus 74%) and less severe (primarily, hemorrhage, requirement for supplemental oxygen, and pulmonary failure). Renal pathologic features were frequently found in both groups (75% of patients with MPA versus 83% of patients with GPA) but tended toward greater severity in those with MPA (primarily, nephrotic-range proteinuria, requirement for dialysis, and end-stage renal disease). Airway/eye involvement was absent among patients with MPA, because these GPA-defining features preclude a diagnosis of MPA within the EMA algorithm. Similar proportions of patients with MPA and those with GPA received combination therapy with corticosteroids plus cyclophosphamide (69% and 78%, respectively) or both drugs in combination with plasmapheresis (19% and 22%, respectively). Other treatments administered, ranging in decreasing frequency from 13% to 3%, were rituximab, methotrexate, azathioprine, and mycophenolate mofetil. Conclusion: Younger age at disease onset and, perhaps, both gastrointestinal manifestations and more severe kidney disease seem to characterize the clinical profile in children with MPA compared to those with GPA. Delay in diagnosis suggests that recognition of these systemic vasculitides is suboptimal. Compared with adults, initial treatment regimens in children were comparable, but the complete reversal of female-to-male disease prevalence ratios is a provocative finding.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988844556&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleComparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Studyen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1002/art.39729en_US
Appears in Collections:Scopus 2016-2017

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