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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/40740
Title: Plasma levels of Galectin-9 reflect disease severity in malaria infection
Authors: Bindongo P.P. Dembele
Haorile Chagan-Yasutan
Toshiro Niki
Yugo Ashino
Noppadon Tangpukdee
Egawa Shinichi
Srivicha Krudsood
Shigeyuki Kano
Toshio Hattori
Tohoku University
Tohoku University School of Medicine
Kagawa University
GalPharma Co., Ltd.
Mahidol University
National Center for Global Health and Medicine
Kibi International University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 11-Aug-2016
Citation: Malaria Journal. Vol.15, No.1 (2016)
Abstract: © 2016 The Author(s). Background: Galectin-9 (Gal-9) is a β-galactoside-binding lectin that interacts with sugar moieties on glycoproteins and glycolipids of cells and pathogens. Gal-9 is known as an immune modulator that induces cell death via interaction with T cell immunoglobulin and mucin domain-3 (Tim3), a co-inhibitory receptor, and it inhibits production of several pro-inflammatory cytokines (TNF, IL-6 and IL-1α) and enhances production of IL-10. To understand the immune pathology of malaria, the Gal-9 in plasma was measured. Methods: Plasma samples and clinical parameters were obtained from 50 acute malaria cases (nine severe and 41 uncomplicated cases) from Thailand at three time points: day 0, day 7 and day 28. Gal-9 levels were determined by ELISA. A total of 38 species of cytokines and chemokines were measured using a BioPlex assay. Results: Gal-9 levels were higher at day 0 compared to day 7 and day 28 (P < 0.0001). Gal-9 levels were also higher in severe malaria (SM) cases compared to uncomplicated (UM) cases at day 0 and day 7 (923 vs 617 pg/mL; P = 0.03, and 659 vs 348 pg/mL; P = 0.02 respectively). Median Gal-9 levels were higher in patients with blood urea nitrogen to creatinine ratio (BUN/creatinine) ≥20 (mg/dL) than in patients with BUN/creatinine <20 (mg/dL) at day 0 (817.3 vs 576.2 pg/mL, P = 0.007). Gal-9 was inversely significantly correlated with chloride levels in both SM and UM cases (r s = -0.73 and r s = -0.46, respectively). In both UM and SM cases, Gal-9 was significantly associated with pro- and anti-inflammatory cytokines and chemokines such as TNF, IL-6, IFN-α2, IFN-γ, IL-1Ra and IL-10. These correlations were observed at day 0 but disappeared at day 28. Conclusions: Gal-9 is released during acute malaria, and reflects its severity. This elevation of Gal-9 in acute malaria infection raises the possibility of its role in termination of the immune response by binding to Tim-3, a receptor of Gal-9.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84981273809&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/40740
ISSN: 14752875
Appears in Collections:Scopus 2016-2017

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