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Title: Species-specific associations between soil-transmitted helminths and micronutrients in Vietnamese schoolchildren
Authors: Brechje De Gier
Tran Thuy Nga
Pattanee Winichagoon
Marjoleine A. Dijkhuizen
Nguyen Cong Khan
Margot Van De Bor
Maiza Campos Ponce
Katja Polman
Frank T. Wieringa
Vrije Universiteit Amsterdam
National Institute of Nutrition Vietnam
Mahidol University
Københavns Universitet
Ministry of Health Vitenam
Prins Leopold Instituut voor Tropische Geneeskunde
Nutrition et Alimentation des Populations aux Suds
Keywords: Immunology and Microbiology
Issue Date: 1-Jul-2016
Citation: American Journal of Tropical Medicine and Hygiene. Vol.95, No.1 (2016), 77-82
Abstract: © Copyright 2016 by The American Society of Tropical Medicine and Hygiene. Soil-transmitted helminth (STH) infections and micronutrient deficiencies are closely related and often coexist among low-income populations. We studied the association between infections with specific STH species and micronutrient status in rural Vietnamese schoolchildren. Children (N = 510) aged 6-9 years were recruited from two primary schools. STH infections were determined in stool samples. Hemoglobin, ferritin, retinol, and zinc were measured in blood samples, as well as C-reactive protein to control for inflammation. Iodine excretion was measured in urine. Associations of single and multiple infections with Ascaris lumbricoides, Trichuris trichiura, and hookworm with micronutrient status (hemoglobin, plasma ferritin, retinol, zinc, and urinary iodine) were estimated by multiple regression analysis. Ascaris infections showed a specific and intensity-dependent negative association with Vitamin A. Trichuris and hookworm infections were associated with lower hemoglobin concentration, but not with plasma ferritin. Trichurisinfected children had zinc deficiency less often than uninfected children. In conclusion, our study shows species-specific associations between STH infections and micronutrient status in children. The different life cycles of STH species might have specific effects on the absorption or loss of specific micronutrients. Tailor-made combinations of deworming and nutritional interventions may be needed to improve child health and nutrition.
ISSN: 00029637
Appears in Collections:Scopus 2016-2017

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